Much clinical research has been undertaken to test and report on the efficacy of both Speleotherapy and Halotherapy since Polish doctor Felix Boczkowski first published his findings in 1843.

Most of the research has been carried out in Europe, where Salt Therapy has grown steadily in popularity for over 150 years.

Many of the clinical trials thus far have focused on the use of Speleotherapy as a treatment for asthma, chronic bronchitis, a range of respiratory conditions and potentially against systemic diseases.

Clinical studies have also been published in the New England Journal of Medicine (2006) demonstrating that the inhalation of saline produces sustained mucus clearance and improved lung function in patients with Cystic Fibrosis. In 1995 the Journal of Aerosol Medicine reported significant improvements in patients with various types of respiratory diseases (bronchial asthma, chronic obstructive and non-obstructive bronchitis, bronchiectasis, cystic fibrosis) who were treated with halotherapy in a placebo-controlled clinical trial.

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Chervinskaya AV, Zilber NA

Halotherapy for treatment of respiratory diseases
Journal of Aerosol Medicine (1995)

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Gorbenko PP, Adamova IV, Sinitsyna TM

Bronchial hyperreactivity to the inhalation of hypo- and hyperosmolar aerosols and its correction by halotherapy
Ter Arkh (1996)

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Grinshtein IuI, Shestovitskii VA, Kuligina-Maksimova AV

Clinical significance of cytological characteristics of bronchial inflammation in obstructive pulmonary diseases
Ter Arkh (2004)

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Grigor'eva NV

Halotherapy in combined non-puncture therapy of patients with acute purulent maxillary sinusitis
Vestn Otorinolaringol (2003)

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Abdrakhmanova LM, Farkhutdinov UR, Farkhutdinov RR

Effectiveness of halotherapy of chronic bronchitis patients
Vopr Kurortol Fizioter Lech Fiz Kult (Nov-Dec 2000)

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Maev EZ, Vinogradov NV

Halotherapy in the combined treatment of chronic bronchitis patients
Voen Med Zh (Jun 1999)

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Chernenkov RA, Chernenkova EA, Zhukov GV

The use of an artificial microclimate chamber in the treatment of patients with chronic obstructive lung diseases
Vopr Kurortol Fizioter Lech Fiz Kult (Jul-Aug 1997)

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Chervinskaia AV

The scientific validation and outlook for the practical use of halo-aerosol therapy
Vopr Kurortol Fizioter Lech Fiz Kult (Jan-Feb 2000)

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Farkhutdinov UR, Abdrakhmanova LM, Farkhutdinov RR

Effects of halotherapy on free radical oxidation in patients with chronic bronchitis
Klin Med, Moscow (2000)

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Borisenko LV, et al

The use of halotherapy for the rehabilitation of patients with acute bronchitis and a protracted and recurrent course
Vopr Kurortol Fizioter Lech Fiz Kult (Jan-Feb 1995)

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Roslaia NA, Likhacheva EI, Shchekoldin PI

Efficacy of therapeutic use of ultrasound and sinusoidal modulated currents combed with halotherapy in patient with occupational toxic-dust bronchitis
Vopr Kurortol Fizioter Lech Fiz Kult (Jan-Feb 2001)

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Maliavin AG, Filiaeva IuA, Umakhanova MM, Chervinskaia AV

Halotherapy-a new treatment of bacterial vaginosis
Vopr Kurortol Fizioter Lech Fiz Kult (May-Jun 2004)

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Headman J, Hugg T, Sandell J, Haahtelat

The effect of salt chamber treatment on hyperresponsiveness in asthmatics
Conclusions: Salt chamber treatment reduced bronchial hyperresponsiveness as an add-on therapy in asthmatics with a low to moderate dose of inhaled steroids. The possibility that salt chamber treatment could serve as a complementary therapy to convention medication cannot be excluded

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Mark R. Elkins, M.H.Sc., Michael Robinson, Ph.D., Barbara R. Rose, Ph.D., Colin Harbour, Ph.D.
Carmel P. Moriarty, R.N., Guy B. Marks, Ph.D., Elena G. Belousova, M.Appl.Sc., Wei Xuan, Ph.D. and
Peter T.P. Bye, Ph.D. for the National Hypertonic Saline in Cystic Fibrosis (NHSCF) Study Group*

The New England Journal of Medicine: A Controlled Trial of Long-Term Inhaled Hypertonic Saline in Patients with Cystic Fibrosis
Conclusions: Hypertonic saline preceded by a bronchodilator is an inexpensive, safe, and effective additional therapy for patients with cystic fibrosis

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Garavello W, Romagnoli M, Sordo L, Gaini RM, Di Berardino C, Angrisano A

Pediatric Allergy and Immunology: Hypersaline nasal irrigation in children with symptomatic seasonal allergic rhinitis:
A randomized study (2003)

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E. Daviskas*, S.D. Anderson*, I. Gonda**, S. Eberl+, S. Meikle+, J.P. Seale+, G. Bautovich+

Inhalation of hypertonic saline aerosol enhances mucociliary clearance in asthmatic and healthy subjects